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 View Full-text : Current Issue |
| Original articles |
Korean J Intern Med. 2010
June;25(2):195-200.
DOI: 10.3904/kjim.2010.25.2.195
Serum Prohepcidin Levels in Helicobacter PyloriInfected Patients with Iron Deficiency Anemia
Sun-Young Lee1, Eun Young Song2, Yeo Min Yun3, So Young Yoon1, Yo Han Cho1, Sung-Yong Kim1, and Mark Hong Lee1
1Department of Internal Medicine, Konkuk University School of Medicine; 2Department of Laboratory Medicine, Seoul National University College of Medicine; 3Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea |
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Background/Aims: Helicobacter pylori (H. pylori) infection appears to subvert the human iron regulatory mechanism and thus upregulates hepcidin, resulting in unexplained iron-deficiency anemia (IDA). We evaluated serum prohepcidin levels before and after eradication of H. pylori in IDA patients to assess whether it plays a role in IDA related to H. pylori infection.
Methods: Subjects diagnosed with unexplained IDA underwent upper gastrointestinal endoscopy and colonoscopy to confirm H. pylori infection and to exclude gastrointestinal bleeding. Blood was sampled before treatment to eradicate H. pylori and again 1 month later. Serum prohepcidin levels were measured using a commercial enzyme-linked immunosorbent assay kit.
Results: Serum prohepcidin levels decreased significantly after oral iron replacement combined with H. pylori eradication (p = 0.011). The reduction ratio of serum prohepcidin levels after the treatment did not differ among the combined oral iron replacement and H. pylori eradication groups, the H. pylori eradication only group, and the iron replacement only group (p = 0.894).
Conclusions: Serum prohepcidin levels decrease after both H. pylori eradication and oral iron administration, with improvement in IDA. Serum concentration of prohepcidin is related to the anemia status, rather than to the current status of H. pylori infection, in IDA patients. (Korean J Intern Med 2010;25:195-200)
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Keywords : Prohepcidin; Anemia, iron-deficiency; Helicobacter pylori |
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eISSN 2005-6648
